1 Introduction: Two Centuries of Progress in Transfusion Medicine   S1
Walter H. (Sunny) Dzik and Michael F. Murphy

Part I Basic Principles of Immunohaematology    S11

2 Essential Immunology for Transfusion Medicine    S11
Jaap Jan Zwaginga and S. Marieke van Ham

3 Human Blood Group Systems    S20
Geoff Daniels

4 Human Leucocyte Antigens    S29
Cristina V. Navarrete and Colin J. Brown

5 Platelet and Neutrophil Antigens    S43
Brian R. Curtis

6 Pretransfusion Testing and the Selection of Red Cell Products for Transfusion    S58
Mark H. Yazer and Meghan Delaney

Part II Complications of Transfusions    S69

7 Investigation of Acute Transfusion Reactions 69
Kathryn E. Webert and Nancy M. Heddle

8 Haemolytic Transfusion Reactions    S81
Edwin J. Massey, Robertson D. Davenport and Richard M. Kaufman

9 Febrile and Allergic Transfusion Reactions    S97
Mark K. Fung and Nancy M. Heddle

10 Lung Injury and Pulmonary Oedema After Transfusion    S108

Steven H. Kleinman and Daryl J. Kor

11 Purported Adverse Effects of ‘Old Blood’    S118
Lirong Qu and Darrell J. Triulzi

12 Transfusion-Induced Immunomodulation    S125

Amy E. Schmidt, Majed A. Refaai, Joanna M. Heal and Neil Blumberg

13 Transfusion-Associated Graft -Versus -Host Disease and Microchimerism    S136

Beth H. Shaz, Richard O. Francis and Christopher D. Hillyer

14 Posttransfusion Purpura    S147

Michael F. Murphy

15 Transfusion-Transmitted Infections    S153

Roger Y. Dodd and Susan L. Stramer

16 Bacterial Contamination    S168

Sandra Ramírez ]Arcos and Mindy Goldman

17 Emerging Infections and Transfusion Safety    S176

Roger Y. Dodd

Part III Practice in Blood Centres and Hospitals    S184

18 Regulatory Aspects of Blood Transfusion    S184
William G. Murphy, Louis M. Katz and Peter Flanagan

19 The Role of Haemovigilance in Transfusion Safety    S193
Katharine A. Downes and Barbee I. Whitaker

20 Donors and Blood Collection    S203

Marc Germain, Ellen McSweeney and William G. Murphy

21 Blood Donation Testing and the Safety of the Blood Supply    S215

Mindy Goldman

22 Production and Storage of Blood Components    S222

Marissa Li, Rebecca Cardigan, Stephen Thomas and Ralph Vassallo

23 Blood Transfusion in Hospitals    S233

Erica M. Wood, Mark H. Yazer and Michael F. Murphy

24 Blood Transfusion in a Global Context    S254

David J. Roberts, Alan D. Kitchen, Stephen P. Field, Imelda Bates, Jean Pierre Allain and Meghan Delaney

Part IV Clinical Transfusion Practice    S264

25 Inherited and Acquired Coagulation Disorders    S264
Irina Chibisov and Franklin Bontempo

26 Massive Blood Loss    S279

John R. Hess

27 Blood Management in Acute Haemorrhage and Critical Care    S287

Gavin J. Murphy, Nicola Curry, Nishith N. Patel and Timothy S. Walsh

28 Point-of-Care Testing in Transfusion Medicine    S302

Matthew D. Neal and Louis H. Alarcon

29 Haematological Disease    S312

Lise J. Estcourt, Simon J. Stanworth and Michael F. Murphy

30 Blood Transfusion in the Management of Patients with Haemoglobinopathies    S330

Enrico M. Novelli

31 Heparin-Induced Thrombocytopenia    S341

Andreas Greinacher and Theodore E. Warkentin

32 Immunodeficiency and Immunoglobulin Therapy    S357

Siraj A. Misbah

33 Transfusing Neonates and Infants    S371

Ronald G. Strauss

Part V Patient Blood Management    S383

34 Development of a Patient Blood Management Programme    S383
Jonathan H. Waters

35 Perioperative Patient Blood Management     S393

Martin Rooms, Ravishankar Rao Baikady and Toby Richards

36 Restrictive Transfusion Practice and How to Implement It    S405

Lawrence Tim Goodnough and Neil Shah

37 Using Data to Support Patient Blood Management    S416

Steven M. Frank and Jack O. Wasey

Part VI Cellular and Tissue Therapy and Organ Transplantation    S429

38 Regulation and Accreditation in Cellular Therapy    S429
Zbigniew (Ziggy) M. Szczepiorkowski and Daniel Hollyman

39 Stem Cell Collection and Therapeutic Apheresis    S442

Khaled El ]Ghariani and Zbigniew (Ziggy) M. Szczepiorkowski

40 Haemopoietic Stem Cell Processing and Storage    S455

Hira Mian, Ronan Foley and Pamela O’Hoski

41 Haematopoietic Stem Cell Transplantation    S466

Robert D. Danby, Rachel Protheroe and David J. Roberts

42 Cord Blood Transplantation   S477

Rachael Hough and Robert D. Danby

43 Recent Advances in Clinical Cellular Immunotherapy S490
Mark W. Lowdell and Emma Morris

44 Tissue Banking    S500

Akila Chandrasekar, Paul Rooney and John N. Kearney

Part VII Development of the Evidence Base for Transfusion    S508

45 Observational and Interventional Trials in Transfusion Medicine    S508
Alan T. Tinmouth, Dean Fergusson and Paul C. Hébert

46 Getting the Most Out of the Evidence for Transfusion Medicine    S520

Simon J. Stanworth, Susan J. Brunskill, Carolyn Dorée and Sally Hopewell

47 A Primer on Biostatistics    S533

Andrew W. Shih and Nancy M. Heddle

48 A Primer on Health Economics    S549
Seema Kacker and Aaron A. R. Tobian

49 Scanning the Future of Transfusion Medicine    S560
Jay E. Menitove, Paul M. Ness and Edward L. Snyder

Glossar, Stichwortverzeichnis