Vorträge zu Individueller Hämotherapie und Patient Blood Management

IAKH Mitglieder können auch die Vorträge zu diesem Thema bei den letzten Transfusionsgesprächen der IAKH runterladen
(Dateien großteils im Power-Point-Format sind frei verfügbar, benötigen aber eine längere Zeit zum Download)
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Ökonomisches Benefit des PBM (ppt)
Finanzierung des PBM (ppt)
NATA-Konzept des PBM (ppt)
Epo-Physiologie und Rezeptormechanismen (ppt)
Eisenstoffwechsel und Anämietherapie (ppt)
Optimal Blood Use der Europäischen Union (pdf)
Individuelle Hämotherapie der IAKH 2011 (ppt)
PBM Ökonomie - Workshop IAKH 2010 (ppt)
EPO, Eisen, alles alte Hüte? (ppt)
Liste der Eingriffe mit vorheriger Anämiediagnostik (pdf)
PBM - Workshop IAKH 2012 (pdf)
Präoperative Anämie - Workshop IAKH 2012 (pdf)

 

 

Interessante Web Links zum Thema Patient Blood Management:

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Patient Blood Management - Initiative und Netzwerkbildung der Uni Frankfurt
Organisation des PBM Konzepts als Konsil - Indikationsliste der Anästhesie Uniklinikum Frankfurt
Information zur Abnahme von Labor-Mikroproben über das Sarstedt System
Checkliste PBM der Uni Frankfurt
Information des österreichischen Gesundheitsministeriums zum PBM - viele nützliche Beschreibungen
Blutverlust und Kompensatorische Mechanismen (Schiferer, Hiesmayer) PDF
Grundzüge des Eisenstoffwechsels (Lanzer) PDF
Präoperative Anämiekorrektur (Cebulla) PDF
PBM auf der Intensivstation (Hiesmayer, Schiferer) PDF
Intraoperatives Vorgehen (Reiter) PDF
Ausschöpfung der Anämietoleranz (Habler) PDF
PBM und Optimal Blood Use (Hinger) PDF

 

 

Ausgewählte wissenschaftliche Artikel zum Patient Blood Management

Zum Transfusionstrigger / Zur Transfusions-Strategie:

Cochrane Analysen zum Thema (Pubmed)

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Februar 2017- Estcourt et al. Restrictive versus liberal red blood cell transfusion strategies for people with haematological malignancies treated with intensive chemotherapy or radiotherapy, or both, with or without haematopoietic stem cell support. Cochrane Database Syst Rev. 2017 Jan 27;1:CD011305. doi: 10.1002/14651858.CD011305.pub2.
Oktober 2016 - Carson et al. Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion. Cochrane Database Syst Rev. 2016 Oct 12;10:CD002042. DOI: 10.1002/14651858.CD002042.pub4.
Oktober 2016 - Moggia et al. Methods to decrease blood loss during liver resection: a network meta-analysis. Cochrane Database Syst Rev. 2016 Oct 31;10:CD010683. DOI: 10.1002/14651858.CD010683.pub3.
August 16 - Desborough et al. Alternatives, and adjuncts, to prophylactic platelet transfusion for people with haematological malignancies undergoing intensive chemotherapy or stem cell transplantation. Cochrane Database Syst Rev. 2016 Aug 22;(8):CD010982. doi: 10.1002/14651858.CD010982.pub2.
April 2016 - Estcourt et al. Preoperative blood transfusions for sickle cell disease. Cochrane Database Syst Rev. 2016 Apr 6;4:CD003149. doi: 10.1002/14651858.CD003149.pub3.
April 2016 - Estcourt et al. Granulocyte transfusions for treating infections in people with neutropenia or neutrophil dysfunction. Cochrane Database Syst Rev. 2016 Apr 29;4:CD005339. doi: 10.1002/14651858.CD005339.pub2.
Oktober 2015 - Wilkinson et al. Red cell transfusion management for patients undergoing cardiac surgery for congenital heart disease. Cochrane Database Syst Rev. 2014 Feb 7;(2):CD009752. doi: 10.1002/14651858.CD009752.pub2.
Oktober 2015 - Gu et al. Comparison of a restrictive versus liberal red cell transfusion policy for patients with myelodysplasia, aplastic anaemia, and other congenital bone marrow failure disorders. Cochrane Database Syst Rev. 2015 Oct 5;(10):CD011577. doi: 10.1002/14651858.CD011577.pub2.
September 2015 - Crighton et al. A therapeutic-only versus prophylactic platelet transfusion strategy for preventing bleeding in patients with haematological disorders after myelosuppressive chemotherapy or stem cell transplantation. Cochrane Database Syst Rev. 2015 Sep 30;(9):CD010981. doi: 10.1002/14651858.CD010981.pub2.
April 2015 - Brunskill et al. Red blood cell transfusion for people undergoing hip fracture surgery. Cochrane Database Syst Rev. 2015 Apr 21;(4):CD009699. doi: 10.1002/14651858.CD009699.pub2.
Dezember 2014 - Gurusamy et al. Iron therapy in anaemic adults without chronic kidney disease. Cochrane Database Syst Rev. 2014 Dec 31;(12):CD010640. doi: 10.1002/14651858.CD010640.pub2.
November 2011 - Whyte et al. Low versus high haemoglobin concentration threshold for blood transfusion for preventing morbidity and mortality in very low birth weight infants. Cochrane Database Syst Rev. 2011 Nov 9;(11):CD000512. doi: 10.1002/14651858.CD000512.pub2.
September 2010 - Jairath et al. Red cell transfusion for the management of upper gastrointestinal haemorrhage. Cochrane Database Syst Rev. 2010 Sep 8;(9):CD006613. doi: 10.1002/14651858.CD006613.pub3.

 

 

Leitlinien und Übersichtsarbeiten

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September 2017 - Carson et al. Indications for and Adverse Effects of Red-Cell Transfusion. N Engl J Med. 2017 Sep 28;377(13):1261-1272. doi: 10.1056/NEJMra1612789.
Februar 2017 - Wang et al. Restrictive versus liberal blood transfusion in patients with coronary artery disease: a meta-analysis. Curr Med Res Opin. 2017 Apr;33(4):761-768. doi: 10.1080/03007995.2017.1280010.
November 2016 - Carson et al. Clinical Practice Guidelines From the AABB: Red Blood Cell Transfusion Thresholds and Storage. JAMA. 2016 Nov 15;316(19):2025-2035. doi: 10.1001/jama.2016.9185.
Mai 2016 - Prescott et al. Impact of restrictive red blood cell transfusion strategies in oncology. Cancer Treat Rev. 2016 May;46:1-8. doi: 10.1016/j.ctrv.2016.03.010.
März 2016 - Docherty et al. Effect of restrictive versus liberal transfusion strategies on outcomes in patients with cardiovascular disease in a non-cardiac surgery setting: systematic review and meta-analysis. BMJ. 2016 Mar 29;352:i1351. doi: 10.1136/bmj.i1351.
Februar 2016 - Van Rermoortel et al. Methodologic quality assessment of transfusion guidelines and evidence base of more restrictive transfusion thresholds. Transfusion. 2016 Feb;56(2):472-80. doi: 10.1111/trf.13385.
Februar 2016 - Rygård et al. Long-term outcomes in patients with septic shock transfused at a lower versus a higher haemoglobin threshold: the TRISS randomised, multicentre clinical trial.ntensive Care Med. 2016 Nov;42(11):1685-1694. DOI: 10.1007/s00134-016-4437-x.
Mai 2015 - Mirski et al. Restrictive and liberal red cell transfusion strategies in adult patients: reconciling clinical data with best practice. Crit Care. 2015 May 5;19:202. doi: 10.1186/s13054-015-0912-y.
März 2015 - Holst et al. Restrictive versus liberal transfusion strategy for red blood cell transfusion: systematic review of randomised trials with meta-analysis and trial sequential analysis. BMJ. 2015 Mar 24;350:h1354. doi: 10.1136/bmj.h1354.
März 2015 - Murphy et al. Liberal or restrictive transfusion after cardiac surgery. N Engl J Med. 2015 Mar 12;372(11):997-1008. doi: 10.1056/NEJMoa1403612.
März 2015 - Carson et al. Liberal versus restrictive blood transfusion strategy: 3-year survival and cause of death results from the FOCUS randomised controlled trial. Lancet. 2015 Mar 28;385(9974):1183-9. doi: 10.1016/S0140-6736(14)62286-8.
Dezember 2014 - Curley et al. Transfusion triggers for guiding RBC transfusion for cardiovascular surgery: a systematic review and meta-analysis. Crit Care Med. 2014 Dec;42(12):2611-24. doi: 10.1097/CCM.0000000000000548.
Mai 2014 - Song et al. Safe application of a restrictive transfusion protocol in moderate-risk patients undergoing cardiac operations. Ann Thorac Surg. 2014 May;97(5):1630-5. doi: 10.1016/j.athoracsur.2013.12.025.
April 2014 - Rhode et al. Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. JAMA. 2014 Apr 2;311(13):1317-26. doi: 10.1001/jama.2014.2726.
Februar 2014 - Salpeter et al. Impact of more restrictive blood transfusion strategies on clinical outcomes: a meta-analysis and systematic review. Am J Med. 2014 Feb;127(2):124-131.e3. doi: 10.1016/j.amjmed.2013.09.017.
November 2013 - Hogshire et al. Red blood cell transfusion: what is the evidence when to transfuse? Curr Opin Hematol. 2013 Nov;20(6):546-51. doi: 10.1097/MOH.0b013e32836508bd.
April 2007- Lacroix et al. Transfusion strategies for patients in pediatric intensive care units. N Engl J Med. 2007 Apr 19;356(16):1609-19. DOI: 10.1056/NEJMoa066240.
Mai 2001 - Hébert et al. Do blood transfusions improve outcomes related to mechanical ventilation? Chest. 2001 Jun;119(6):1850-7. PMID: 11399714.

 

 

Randomisierte Studien zu "Patient Blood Management"

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Dezember 2017 - Mazer, Whitlock, Fergusson et al. Restrictive or Liberal Red-Cell Transfusion for Cardiac Surgery. N Engl J Med 2017;377:2133-2144. doi: 10.1056/NEJMoa1711818.

 

 

Observationsstudien und Meta-Analysen
(Exceldatei mit Charakteristiken (Stand Januar 2017))

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Januar 2017 - Kansagra et al. Blood Management Strategies after Elective Lower-Extremity Joint Arthroplasty Surgeries. Am J Med Qual. 2017 Nov/Dec;32(6):668-674. doi: 10.1177/1062860616687035.
Excel-Tabelle - Meta-Analysen
Excel-Tabelle - Prospektive Kohorten
Excel-Tabelle - Retrospektive Kohorten

 

 

Ökonomische Berechnungen

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Kosten und Behandlungsqualität des Gesundheitswesens (Leahy, Hofman, et al. Transfusion 2017)
Kosten der Bluttransfusion fürs Krankenhaus (Shander, Hofman, et al. Transfusion 2010)
Die australische Benchmark-Studie (Gombotz et al. Transfusion 2007)
Kosten der Bluttransfusion - richtig gerechnet (Shander, Hofman, Gombotz, et al. Best Pract Res Clin Anaesthesiol 2007)

 

 

Zur Eisen- und EPO-Therapie

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Februar 2016 - Mhaskar et al. The role of iron in the management of chemotherapy-induced anemia in cancer patients receiving erythropoiesis-stimulating agents. Cochrane Database Syst Rev. 2016 Feb 4;2:CD009624. Cochrane Database Syst Rev. 2016 Feb 4;2:CD009624. doi: 10.1002/14651858.CD009624.pub2.
Dezember 2015 - Ng et al. Iron therapy for pre-operative anaemia. Cochrane Database Syst Rev. 2015 Dec 22;(12):CD011588. doi: 10.1002/14651858.CD011588.pub2.
August 2015 - Markova et al. Treatment for women with postpartum iron deficiency anaemia. Cochrane Database Syst Rev. 2015 Aug 13;(8):CD010861. doi: 10.1002/14651858.CD010861.pub2.
Dezember 2014 - Gurusamy et al. Iron therapy in anaemic adults without chronic kidney disease. Cochrane Database Syst Rev. 2014 Dec 31;(12):CD010640. doi: 10.1002/14651858.CD010640.pub2.
April 2014 - Aher et Ohlsson. Late erythropoietin for preventing red blood cell transfusion in preterm and/or low birth weight infants.Rev. Cochrane Database Syst Rev. 2014 Apr 23;(4):CD004868. doi: 10.1002/14651858.CD004868.pub4.
September 2012 - Ohlsson et al. Early erythropoietin for preventing red blood cell transfusion in preterm and/or low birth weight infants. Cochrane Database Syst Rev. 2012 Sep 12;(9):CD004863. doi: 10.1002/14651858.CD004863.pub3.

 

 

Zu POCT & Gerinnungsmanagement (RCTs und Meta-Analysen)

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Februar 2017 - Topsoee et al. A systematic review and meta-analysis of the effect of prophylactic tranexamic acid treatment in major benign uterine surgery. Int J Gynaecol Obstet. 2017 Feb;136(2):120-127. doi: 10.1002/ijgo.12047.
Januar 2017 - Chen et al. Comparison of the effectiveness and safety of topical versusintravenous tranexamic acid in primary total knee arthroplasty: a meta-analysis of randomized controlled trials. Orthop Surg Res. 2017 Jan 19;12(1):11. doi: 10.1186/s13018-017-0512-4.
Januar 2017 - Zeng et al. Intravenous Combined with Topical Administration of Tranexamic Acid in Primary Total Hip Arthroplasty: A Randomized Controlled Trial. Orthop Surg. 2017 May;9(2):174-179. doi: 10.1111/os.12287.
Dezember 2016 - Fraval et al. OBTAIN A: Outcome Benefits of Tranexamic Acid in Hip Arthroplasty. A Randomized Double-Blinded Controlled Trial. J Arthroplasty. 2017 May;32(5):1516-1519. doi: 10.1016/j.arth.2016.11.045.
Dezember 2016 - Dallaku et al. Effects of tranexamic acid on platelet function and thrombin generation (ETAPlaT): WOMAN trial sub-study. Wellcome Open Res. 2016 Dec 15;1:29. doi: 10.12688/wellcomeopenres.9964.1
August 2016 - Wikkelsø et al. Thromboelastography (TEG) or thromboelastometry (ROTEM) to monitor haemostatic treatment versus usual care in adults or children with bleeding. Cochrane Database Syst Rev. 2016 Aug 22;(8):CD007871. doi: 10.1002/14651858.CD007871.pub3.
März 2016 - Estcourt et al. Antifibrinolytics (lysine analogues) for the prevention of bleeding in people with haematological disorders. Cochrane Database Syst Rev. 2016 Mar 15;3:CD009733. doi: 10.1002/14651858.CD009733.pub3.
Juli 2015 - Johansen et al. Prothrombin complex concentrate for reversal of vitamin K antagonist treatment in bleeding and non-bleeding patients. Cochrane Database Syst Rev. 2015 Jul 7;(7):CD01055. doi: 10.1002/14651858.CD010555.pub2.
Juli 2015 - Desborough et al. Fresh frozen plasma for cardiovascular surgery. Cochrane Database Syst Rev. 2015 Jul 14;(7):CD007614. doi: 10.1002/14651858.CD007614.pub2.
März 2013 - Butler et al. Pathogen-reduced platelets for the prevention of bleeding. Cochrane Database Syst Rev. 2013 Mar 28;(3):CD009072. doi: 10.1002/14651858.CD009072.pub2.
März 2011 - Henry et al. Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion. Cochrane Database Syst Rev. 2011 Mar 16;(3):CD001886. doi: 10.1002/14651858.CD001886.pub4.
April 2009 - Sibylle A Kozek-Langenecker: Die strukturierte Gerinnungsanamnese - Der ÖGARI-Fragebogen
Februar 2001 - Henry et al. Desmopressin for minimising perioperative allogeneic blood transfusion. Cochrane Database Syst Rev. 2001;(2):CD001884. DOI: 10.1002/14651858.CD001884.

 

 

Zum Lagerungsschaden

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Januar 2016 - Rapido et al. Prolonged red cell storage before transfusion increases extravascular hemolysis. J Clin Invest 2017; 127: 375-82.
Juli 2015 - Marti-Carvajal et al. Prolonged storage of packed red blood cells for blood transfusion. Cochrane Database Syst Rev. 2015 Jul 14;(7):CD009330. doi: 10.1002/14651858.CD009330.pub2.
Mai 2015 - Brunskill et al. Transfusion of fresher versus older red blood cells for all conditions. Cochrane Database Syst Rev. 2015 May 12;(5):CD010801. doi: 10.1002/14651858.CD010801.pub2.

 

 

Programm-Proklamation zum Patient Blood Management

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Deutsches Ärzteblatt 2013 - Patient Blood Management: Kluger Umgang mit einer wertvollen Ressource
DRK-Hämotherapie - Patient Blood Management
American Association of Blood Banks
Weltgesundheitsorgansiation WHO - Patient Blood Management
Europäische Union - Optimal Blood Use

 

 

Literatur

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Thieme Buch Gombotz, Zacharowski, Spahn


siehe auch IAKH Seite Literaturempfehlung

 

 

Hilfreiche Tools zum Programm Patient Blood Management

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Monovetten mit Microfüllung
Geschlossene Blutentnahme und Rückgabesysteme
Kitteltascheninformationen zu Blutprodukten
Muster - Gerinnungsanamnesebogen der IAKH zur präoperativen Erfassung von Gerinnungsstörungen
Muster - Klinikpfad der IAKH "Elektive Endoprothetik"
Muster - Patienteninformation der IAKH zur präoperativen Anämie
Muster - PDF Abholschein (Klinikverbund Südwest, Copyright für die IAKH erteilt)